Abstract

Research Article

Coronavirus COVID-19 surface properties: Electrical charges status

Luisetto M*, Tarro G, Khaled Edbey, Farhan Ahmad Khan, Yesvi AR, Nili BA, Fiazza C, Mashori GR, President, IMA Academy and Italy

Published: 13 April, 2021 | Volume 4 - Issue 1 | Pages: 016-027

Aim of this work is to analyze the coronavirus viral surface properties related the pattern of electrical features.

This chemical physical property is relevant and crucial to set profile of diffusion, severity of disease, efficacy of therapeutic strategy and in order to search new way to fight COVID-19 and the NEW VARIANT.

The phenomena of immune evasion and the different pattern of efficacy towards variants of some vaccine or some antibodies combination produce the need to verify if considering the electrical feature of viral surface can be a right tool or not.

As result of this research it is possible to submit to the scientist that the viral surface properties and electrical feature can be an element to be considered in various preventive or treatment measure.

The specificity of action of some vaccine or antibodies seem to tell us that also the aspecific methods are useful.

A specific chemico physical factors can influence the electrical charges viral surface behavior.

Hpertonic saline solution, humidity, electrical charge barrier in mask are simply example of the effect.

That can be obtained action on viral surface chemico -physical properties.

Read Full Article HTML DOI: 10.29328/journal.ijcmbt.1001021 Cite this Article Read Full Article PDF

Keywords:

Coronavirus; COVID-19; Envelope; Electrical charge; Severity of disease; Spread; Surface chemical physical properties; New strategy; Specific and aspecific measure

References

  1. Rakshita K, Chatterjeea S, Bandyopadhyaya D, Sarkarb S. Preprint an effective approach to reduce the penetration potential of sarscov-2 and other viruses by spike protein: surface particle.
  2. Schoeman D, Fielding BC. Coronavirus envelope protein: current knowledge. Virol J. 2019; 16: 69. PubMed: https://pubmed.ncbi.nlm.nih.gov/31133031/
  3. Northwestern University Amanda Morris Research exposes new vulnerability for SARS-CoV-2. Electrostatic interactions enhance the spike protein's bond to host cells. 2020.
  4. Leung WWF, Sun Q. Electrostatic charged nanofiber filter for filtering airborne novel coronavirus (COVID-19) and nano-aerosols. Sep Purif Technol. 2020; 250: 116886. PubMed: https://pubmed.ncbi.nlm.nih.gov/32322159/
  5. Sholanov K. Electrophysical processes effecting the covid-19 virus before it enters. Organism.
  6. Li W. Structurally Observed Electrostatic Features of the COVID-19 Coronavirus-Related Experimental. Structures inside Protein Data Bank: A Brief Update.
  7. Luisetto M. Chemico- physicals properties of coronavirus affecting. Int Invent Sci J. 2021; 5:
  8. Baron J, El-Chaar G. Hypertonic Saline for the Treatment of Bronchiolitis in Infants and Young Children: A Critical Review of the Literature. J Pediatr Pharmacol Ther. 2016; 21: 7–26. PubMed: https://pubmed.ncbi.nlm.nih.gov/26997926/
  9. Biktasheva IV. Role of a habitat's air humidity in Covid-19 mortality. Sci Total Environ. 2020; 736: 138763. PubMed: https://pubmed.ncbi.nlm.nih.gov/32492610/
  10. Jing JLJ, Yi TP, Bose RJC, McCarthy JR, Tharmalingam N, et al. Hand Sanitizers: A Review on Formulation Aspects, Adverse Effects, and Regulations. Int J Environ Res Public Health. 2020; 17: 3326. PubMed: https://pubmed.ncbi.nlm.nih.gov/32403261/
  11. Pawłowski PH. Charged amino acids may promote coronavirus SARS-CoV-2 fusion with the host cell. AIMS Biophysics. 2021; 8: 111–120. PubMed: http://www.aimspress.com/journal/biophysics
  12. Al Ahmad M, Mustafa F, Ali LM, Rizvi TA. Virus detection and quantification using electrical parameters. Sci Rep. 2014; 4: 6831. PubMed: https://pubmed.ncbi.nlm.nih.gov/25355078/
  13. MacCuspie RI, Nuraje N, Lee SY, Runge A, Matsui H. Comparison of Electrical Properties of Viruses Studied by AC Capacitance Scanning Probe Microscopy. J Am Chem Soc. 2008; 130: 887–891. PubMed: https://pubmed.ncbi.nlm.nih.gov/18092777/
  14. Kettleson EM, Ramaswami B, Hogan CJ, Jr., Lee MH, Statyukha GA, et al. Airborne Virus Capture and Inactivation by an Electrostatic Particle Collector. Environ Sci Technol. 2009; 43: 5940–5946. PubMed: https://pubmed.ncbi.nlm.nih.gov/19731701/
  15. Scheller C, Krebs F, Minkner R, Astne I, Gil‐Moles M, et al. Physicochemical properties of SARS‐CoV‐2 for drug targeting, virus inactivation and attenuation, vaccine formulation and quality control. 2020.
  16. Hagbom M, Nordgren J, Nybom R, Hedlund KO, Wigzell H, et al. Ionizing air affects influenza virus infectivity and prevents airborne-transmission. Sci Rep. 2015; 5: 11431.
  17. Xie Y, Karki CB, Du D, Li H, Wang J, et al. Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind with Human ACE2. Front Mol Biosci. 2020; 7: 591873. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755986/
  18. Wang ZY, Li XD, Sun AL, Fu XQ. Efficacy of 3% hypertonic saline in bronchiolitis: A meta-analysis. Exp Ther Med. 2019; 18: 1338–1344. PubMed: https://pubmed.ncbi.nlm.nih.gov/31384334/
  19. Schaldach CM, Bourcier WL, Shaw HF, Viani BE, Wilson WD. The influence of ionic strength on the interaction of viruses with charged surfaces under environmental conditions. J Colloid Interface Sci. 2006; 294: 1-10. PubMed: https://pubmed.ncbi.nlm.nih.gov/16083898/
  20. Rafael RG. Machado F, Glaser T, Araujo DB, Petiz LL, et al. Hypertonic saline solution inhibits SARS-CoV-2 in vitro assay.
  21. Rakshit K. An Effective Approach to Reduce the Penetration Potential of SARS-CoV-2 and other Viruses by Spike Protein; AIJR Preprints. 2020.
  22. Morton SP, Phillips JL. Computational Electrostatics Predict Variations in SARS-CoV-2 Spike and Human ACE2 Interactions. BioRxiv. 2020

Figures:

Figure 1

Figure 1

Figure 1

Figure 2

Figure 1

Figure 3

Figure 1

Figure 4

Figure 1

Figure 5

Figure 1

Figure 6

Figure 1

Figure 7

Figure 1

Figure 8

Figure 1

Figure 9

Figure 1

Figure 10

Figure 1

Figure 11

Figure 1

Figure 12

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?